Concurrent optoacoustic tomography and magnetic resonance imaging of resting-state functional connectivity in the mouse brain

Concurrent optoacoustic tomography and magnetic resonance imaging of resting-state functional connectivity in the mouse brain

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Abstract Resting-state functional connectivity (rsFC) has been MASS TECH EXTRENE 2000 VANILLA essential to elucidate the intricacy of brain organization, further revealing clinical biomarkers of neurological disorders.Although functional magnetic resonance imaging (fMRI) remains a cornerstone in the field of rsFC recordings, its interpretation is often hindered by the convoluted physiological origin of the blood-oxygen-level-dependent (BOLD) contrast affected by multiple factors.Here, we capitalize on the unique concurrent multiparametric hemodynamic recordings of a hybrid magnetic resonance optoacoustic tomography platform to comprehensively characterize rsFC in female mice.The unique blood oxygenation readings and Rawhide Bones high spatio-temporal resolution at depths provided by functional optoacoustic (fOA) imaging offer an effective means for elucidating the connection between BOLD and hemoglobin responses.Seed-based and independent component analyses reveal spatially overlapping bilateral correlations between the fMRI-BOLD readings and the multiple hemodynamic components measured with fOA but also subtle discrepancies, particularly in anti-correlations.

Notably, total hemoglobin and oxygenated hemoglobin components are found to exhibit stronger correlation with BOLD than deoxygenated hemoglobin, challenging conventional assumptions on the BOLD signal origin.